Plasmid pORF-hTRAIL targeting to glioma using transferrin-modified polyamidoamine dendrimer
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چکیده
منابع مشابه
Plasmid pORF-hTRAIL targeting to glioma using transferrin-modified polyamidoamine dendrimer
A gene drug delivery system for glioma therapy based on transferrin (Tf)-modified polyamidoamine dendrimer (PAMAM) was prepared. Gene drug, tumor necrosis factor-related apoptosis-inducing ligand (hTRAIL)-encoding plasmid open reading frame (pORF-hTRAIL, Trail), was condensed by Tf-modified PAMAM to form nanoparticles (NPs). PAMAM-PEG-Tf/DNA NPs showed higher cellular uptake, in vitro gene expr...
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ژورنال
عنوان ژورنال: Drug Design, Development and Therapy
سال: 2015
ISSN: 1177-8881
DOI: 10.2147/dddt.s95843